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INRA
24, chemin de Borde Rouge –Auzeville – CS52627
31326 Castanet Tolosan CEDEX - France

Dernière mise à jour : Mai 2018

Menu logo inrae University of Strasbourg

UMR SVQV

Zone de texte éditable et éditée et rééditée

Véronique Brault

Véronique Brault
Senior scientist

(+33) 06 67 77 98 90

Senior scientist

Deputy of the research unit director

Plant virus transmission by aphids: a series of several episodes…

Studying the molecular mechanisms of the aphid transmission of poleroviruses is our main objective. First we identified the viral determinants required for polerovirus transmission, and then, we looked for phloem proteins able to bind virions in the sap. These proteins acquired by the aphids together with the virus are potentially involved in virus transmission. More recently and after years of extensive work we identified a polerovirus receptor in the aphid. We are now studying the cross-talk between the plant, the virus and the aphid to identify the deregulations induced by the viral infection in the plant which impact the aphid behavior and potentially the virus transmission. Our ultimate goal is to identify targets to inhibit the aphid transmission process in order to develop alternatives to insecticide treatments.

Research projects  

  • Cross-talk between plant, polerovirus and aphids: ROME project
  • Molecular mechanisms of polerovirus transmission by aphids
  • Virus tracking in the plants and in aphids using fluorescent or luminescent flags to label the virus

List of selected publications

Brault V. and Miller W.A. (1992) Translational frameshifting mediated by a viral sequence in plant cells. PNAS USA 89, 2262-2266.

Brault V., Van den Heuvel J.F.J.M., Verbeek M., Ziegler-Graff V., E., Reutenauer A., Herrbach E., Garaud J.C., Guilley H., Richards K. and Jonard G. (1995) Aphid transmission of Beet western yellows luteovirus requires the minor capsid readthrough protein P74. EMBO J. 14, 650-659.

Brault V., Mutterer J., Scheidecker D., Simonis M-T., Herrbach E., Richards K. and Ziegler-Graff V. (2000) Effects of point mutations in the readthrough domain of the Beet western yellows virus minor capsid protein on virus accumulation in planta and on transmission by aphids. J. Virology 74, 1140-1148.

Brault V., Bergdoll M., Mutterer J., Prasad V., Pfeffer S., Erdinger M., Richards K.E. and Ziegler-Graff V. (2003) Effects of point mutations in the major capsid protein of Beet western yellows virus on capsid formation, virus accumulation and on aphid transmission. J. Virology 77, 3247-3256.

Brault V., Périgon S., Reinbold C., Erdinger M., Scheidecker D., Herrbach E., Richards K. and Ziegler-Graff V. (2005) The polerovirus minor capsid protein determines vector specificity and intestinal tropism in the aphid. J. Virology 79, 9685-9693.

Bencharki, B., Boissinot, S., Revollon, S., Ziegler-Graff, V., Erdinger, M., Wiss, L., Dinant, S., Renard, D., Beuve, M., Lemaitre-Guillier, C., Brault, V. (2010). Phloem protein partners of Curcurbit aphid borne yellows virus: possible involvement of phloem proteins in virus transmission by aphids. Molecular Plant-Microbe Interactions 23(6): 799-810.

Reinbold, C., Lacombe, S., Ziegler-Graff, V., Scheidecker, D., Wiss, L., Beuve, M., Caranta, C., Brault, V. (2013) Closely related poleroviruses depend on distinct translation initiation factors to infect Arabidopsis thaliana. MPMI 26, 257-265

Boissinot, S., Erdinger, M., Monsion, B., Ziegler-Graff, V., Brault, V. (2014) Both structural and non-structural forms of the readthrough protein of Cucurbit aphid-borne yellows virus are essential for efficient systemic infection of plants. PloS One 9(4):e93448 

Boissinot S, Pichon E, Sorin C, Piccini C, Scheidecker D, Ziegler-Graff V, Brault V. (2017) Systemic propagation of a fluorescent infectious clone of Turnip yellows virus following agroinoculation and aphid transmission. Viruses 9, 166; doi:10.3390/v9070166

Heck M, Brault V (2018) Targeted disruption of aphid transmission: a vision for the management of crop diseases caused by Luteoviridae members. Current Opinion in Virology, 33, 24-32; DOI:10.1016/j.coviro.2018.07.007 

Mulot M, Monsion B, Boissinot S, Rastegar M, Meyer S, Bochet N, Brault V (2018) Transmission of Turnip yellows virus by Myzus persicae is reduced by feeding aphids on double-stranded RNA targeting the ephrin receptor protein. Frontiers in Microbiology, 9, 457; DOI:10.3389/fmicb.2018.00457

Education and professional carreer

1990 : PhD from the University of Bordeaux (France) on Pathogen-derived resistance against a grapevine nepovirus supervised by Dr Thierry Candresse.

1990-1992 : 2 years post-doctoral position in Pr Allen Miller’s lab at the Iowa State University (Ames, Iowa, USA) to study the translation mechanisms of luteoviruses infecting cereals.

1993: Post-doctoral position in Pr Gérard Jonard’s lab at the CNRS/IBMP in Strasbourg (France) working on the identification of the viral determinants involved in polerovirus transmission by aphids.

1993 : Scientific researcher at the CNRS/IBMP in Strasbourg (France) working on polerovirus transmission by aphids.

2004: Scientific researcher at the Inra of Colmar in the team studying virus transmission by vectors to develop research on the molecular mechanisms of polerovirus transmission by aphids. 

Now : Scientific Director in the Virus Transmission Team and deputy of the unit director.

Collaborations

  • Long-lasting collaboration with the team of Véronique Ziegler-Graff at the CNRS/IBMP in Strasbourg (France)
  • Member of an Inra network on aphids and associated organisms BAPOA